The Principles and Practice of Medicine
The Principles and Practice of Medicine: Designed for the Use of Practitioners and Students of Medicine is a medical textbook by Sir William Osler
William Osler
Sir William Osler, 1st Baronet was a physician. He was one of the "Big Four" founding professors at Johns Hopkins Hospital as the first Professor of Medicine and founder of the Medical Service there. Sir William Osler, 1st Baronet (July 12, 1849 – December 29, 1919) was a physician. He was...

. It was first published in 1892 while Osler was Professor of Medicine at Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...

. It established Osler as the world's leading authority in the teaching of modern medicine. The textbook was translated into French, German, Russian, Portuguese, Spanish and Chinese and for over 40 years it was the most significant medical textbook.
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