The City is the principal setting of The Tick (comic book)

The Tick (comic book)

The Tick was a comic book series created by Ben Edlund in 1988 and originally published in black-and-white by the New England Comics store in Boston, Massachusetts. The series provided modest beginnings for its title character, who would later feature in his own television programs and merchandise...

, The Tick (TV series), and The Tick (2001 TV series).
Little information is given about the origins of the city. It also acts as a parody of the vagueness of cities in most comic books. From the little information given it can be said that the city is an urban area that resembles Gotham and Metropolis.