The Brain Drain was a BBC

BBC

The British Broadcasting Corporation is a British public service broadcaster. Its headquarters is at Broadcasting House in the City of Westminster, London. It is the largest broadcaster in the world, with about 23,000 staff...

 comedy panel show that ran for 2 seasons in the early 1990s.

Presented by Jimmy Mulville

Jimmy Mulville

James Thomas "Jimmy" Mulville is an English comedian, comedy writer, producer and television presenter. Jimmy Mulville is best known for co-founding in 1986 the British independent television production company Hat Trick Productions with Denise O'Donoghue and Rory McGrath...

 and featuring a panel of 4 performers (including regular panellists Tony Hawks

Tony Hawks

Antony Gordon Hawksworth, better known as Tony Hawks, is a British comedian and author.-Early life:Born in Brighton in 1960, Hawks was educated at Brighton Hove and Sussex Grammar School and Brighton College...

 and (in the 2nd season) Jo Brand

Jo Brand

Josephine Grace "Jo" Brand is a BAFTA winning British comedian, writer, and actor.- Early life :Jo Brand was born 23 July 1957 in Wandsworth, London. Her mother was a social worker. Brand is the middle of three children, with two brothers...

), the show was essentially a comedy version of Question Time

Question Time

Question time in a parliament occurs when members of the parliament ask questions of government ministers , which they are obliged to answer. It usually occurs daily while parliament is sitting, though it can be cancelled in exceptional circumstances...

. Panellists were asked a question by a member of the studio audience (including occasional celebrity guests) to which they were invited to give a humorous response.