Tezosentan
Encyclopedia
Tezosentan is a non-selective ETA
and ETB
receptor antagonist
. It acts as a vasodilator and was designed as a therapy for patients with acute heart failure. Recent studies have shown however, that tezosentan does not improve dyspnea
or reduce the risk of fatal or nonfatal cardiovascular events.
Endothelin receptor type A
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.-Interactions:Endothelin receptor type A has been shown to interact with HDAC7A and HTATIP.-Further reading:...
and ETB
Endothelin receptor type B
Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene.- Function :Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three...
receptor antagonist
Endothelin receptor antagonist
A endothelin receptor antagonist is a drug that blocks endothelin receptors.Three main kinds of ERAs exist:* selective ETA receptor antagonists , which affect endothelin A receptors....
. It acts as a vasodilator and was designed as a therapy for patients with acute heart failure. Recent studies have shown however, that tezosentan does not improve dyspnea
Dyspnea
Dyspnea , shortness of breath , or air hunger, is the subjective symptom of breathlessness.It is a normal symptom of heavy exertion but becomes pathological if it occurs in unexpected situations...
or reduce the risk of fatal or nonfatal cardiovascular events.