Teplizumab
Encyclopedia
Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug
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Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
It targets at protecting the remaining beta cells in newly diagnosed T-1 diabetics. It has been used experimentally in type 1 diabetes mellitus, but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".
Eli Lilly licensed the drug back in 2007 from MacroGenics with a $41 million upfront and a billion dollars pledged for milestones.
It is in Phase-3 clinical trials for Type-1 DM.
One-year data from one phase III trial was disappointing.
Immunosuppressive drug
Immunosuppressive drugs or immunosuppressive agents are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:...
.
Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
It targets at protecting the remaining beta cells in newly diagnosed T-1 diabetics. It has been used experimentally in type 1 diabetes mellitus, but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".
Eli Lilly licensed the drug back in 2007 from MacroGenics with a $41 million upfront and a billion dollars pledged for milestones.
It is in Phase-3 clinical trials for Type-1 DM.
One-year data from one phase III trial was disappointing.
External links
- MacroGenics, Inc.
- Tested: A Reboot for the Immune System at Popular SciencePopular SciencePopular Science is an American monthly magazine founded in 1872 carrying articles for the general reader on science and technology subjects. Popular Science has won over 58 awards, including the ASME awards for its journalistic excellence in both 2003 and 2004...