Tegafur
Encyclopedia
Tegafur is a chemotherapeutic fluorouracil
prodrug
used in the treatment of cancers. It is a component of the combination drug tegafur-uracil
. When metabolized, it becomes 5-fluorouracil.
Fluorouracil
Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites...
prodrug
Prodrug
A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...
used in the treatment of cancers. It is a component of the combination drug tegafur-uracil
Tegafur-uracil
Tegafur-uracil is a chemotherapy drug used in the treatment of cancer, primarily bowel cancer. It is also called UFT or UFUR.-Development and regulation:...
. When metabolized, it becomes 5-fluorouracil.