Tazobactam
Encyclopedia
Tazobactam is a compound that inhibits the action of bacterial beta-lactamase
s. It is added to the extended spectrum beta-lactam
antibiotic
piperacillin
to produce Tazocin or Zosyn or Piprataz. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.
Beta-lactamase
Beta-lactamases are enzymes produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephamycins, and carbapenems . These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam...
s. It is added to the extended spectrum beta-lactam
Beta-lactam antibiotic
β-Lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contains a β-lactam nucleus in its molecular structure. This includes penicillin derivatives , cephalosporins , monobactams, and carbapenems...
antibiotic
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
piperacillin
Piperacillin
Piperacillin is an extended spectrum beta-lactam antibiotic of the ureidopenicillin class.It is normally used together with a beta-lactamase inhibitor such as tazobactam. The combination drug piperacillin/tazobactam is commercially available as e.g. Tazocin, Zosyn, Brodactam, Piptaz and as Trezora...
to produce Tazocin or Zosyn or Piprataz. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.