Tachykinin receptor
Encyclopedia
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C
, producing inositol triphosphate
(so called Gq-coupled).
(Hökfelt
et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
Phospholipase C
Phosphoinositide phospholipase C is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. In general, this enzyme is denoted as Phospholipase C, although three other families of phospholipase C enzymes have been identified in bacteria and in...
, producing inositol triphosphate
Inositol triphosphate
Inositol trisphosphate or inositol 1,4,5-trisphosphate , together with diacylglycerol , is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell...
(so called Gq-coupled).
Binding
The genes and receptor ligands are as follows:| Receptor | Gene | Preferred ligand >- | NK1 Tachykinin receptor 1 The tachykinin receptor 1 also known as neurokinin 1 receptor or substance P receptor is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins... |
substance P Substance P In the field of neuroscience, substance P is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P and its closely related neuropeptide neurokinin A are produced from a polyprotein precursor... >- | NK2 Tachykinin receptor 2 Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.-Selective Ligands:Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an... |
neurokinin A Neurokinin A Neurokinin A is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin A gene as the neuropeptide substance P. It has various roles in the body of humans and other animals... >- | NK3 Tachykinin receptor 3 Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.- Function :This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence... |
neurokinin B Neurokinin B Neurokinin B is a tachykinin peptide.It is found in higher concentration in pregnant women suffering pre-eclampsia and can bind the immune-cloaking molecule phosphocholine.... |
(Hökfelt
Tomas Hökfelt
Tomas Hökfelt is a Swedish physician and former professor in histology at the Karolinska Institutet from 1979 until 2006, when he got his emeritate. He was linked to the Department of Neuroscience and is specialized in cell biology....
et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)