TRPV5
Encyclopedia
Transient receptor potential cation channel subfamily V member 5 is a protein
that in humans is encoded by the TRPV5 gene
.
TRPV5 is mainly expressed in kidney
epithelial cells, where it plays an important role in the reabsorption of Ca2+.. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consquentual hyperparathyroidism
, and bone loss..
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the TRPV5 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
TRPV5 is mainly expressed in kidney
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
epithelial cells, where it plays an important role in the reabsorption of Ca2+.. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consquentual hyperparathyroidism
Hyperparathyroidism
Hyperparathyroidism is overactivity of the parathyroid glands resulting in excess production of parathyroid hormone . The parathyroid hormone regulates calcium and phosphate levels and helps to maintain these levels...
, and bone loss..