Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.

Functions of TACI

TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.

Medical significance

TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID

Cvid

Cvid stands for*Common variable immunodeficiencyand is also used to refer to the video codec Compact Video or*Cinepak*Cvid also stands for Dollar...

 patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.

Interactions

TNFRSF13B has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with B-cell activating factor

B-cell activating factor

B-cell activating factor also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFLSF13B gene...

, TRAF6

TRAF6

TRAF6 is a TRAF human protein.-Interactions:TRAF6 has been shown to interact with SDCBP, IRAK2, IRAK1, MAP3K7IP2, MAP3K7IP1, TNFRSF13B, FHL2, CD40, IKBKG, RANK, HSPB2, UBE2N, SIGIRR, TAX1BP1, ASK1, PPP4C, TNFAIP3, Sequestosome 1, MAP3K7 and Ubiquitin C....

, TRAF5

TRAF5

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.-Interactions:TRAF5 has been shown to interact with ASK1, TNFRSF13B, CD134, CD30, CD40, RANK and TNFRSF14.-Further reading:...

, TNFSF13

TNFSF13

Tumor necrosis factor ligand superfamily member 13 also known as a proliferation-inducing ligand is a protein that in humans is encoded by the TNFSF13 gene. TNFSF13 has also been designated CD256 .- Function :The protein encoded by this gene is a member of the tumor necrosis factor ligand ...

, TRAF2

TRAF2

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.-Interactions:TRAF2 has been shown to interact with BCL10, CD30, CFLAR, IKK2, MAP3K7IP2, CD137, Caveolin 1, CD27, TNFRSF13B, TANK-binding kinase 1, TRAF1, CD40, UBE2N, MAP3K14, MAP4K2, CASP8AP2, HIVEP3,...

 and CAMLG

CAMLG

Calcium signal-modulating cyclophilin ligand is a protein that in humans is encoded by the CAMLG gene.-Interactions:CAMLG has been shown to interact with TNFRSF13B.-Further reading:...

.

Further reading