TIMI
Encyclopedia
TIMI stands for 'Thrombolysis
In Myocardial Infarction
' and is the name of an Academic Research Organization (ARO) which was founded by Dr. Eugene Braunwald
in 1984. It has conducted numerous practice-changing clinical trials in patients with cardiovascular disease or risk factors for cardiovascular disease.
The TIMI Study Group is affiliated with Brigham and Women's Hospital and Harvard Medical School, and is chaired by Dr. Marc Sabatine (founding Chairman Eugene Braunwald
, MD (1982-2010)). Its headquarters are located in Boston, MA with a second location in Quincy, MA.
TIMI Score Calculation (1 point for each):
-Age >= 65
-Aspirin use in the last 7 days (patient experiences chest pain despite ASA use in past 7days)
-At least 2 angina episodes within the last 24hrs
-ST changes of at least 0.5mm on admission EKG
-Elevated serum cardiac biomarkers
-Known Coronary Artery Disease (CAD) (coronary stenosis >= 50%)
- At least 3 risk factors for CAD, such as: Hypertension -> 140/90 or on antihypertensives, Cigarette smoking, HDL < 40, Diabetes,
Family history of premature CAD (CAD in male first-degree relative, or father less than 55, or female first-degree relative or mother less than 65).
Score Interpretation:
% risk at 14 days of: all-cause mortality, new or recurrent MI, or severe recurrent ischemia requiring urgent revascularization.
Score of 0-1 = 4.7% risk
Score of 2 = 8.3% risk
Score of 3 = 13.2% risk
Score of 4 = 19.9% risk
Score of 5 = 26.2% risk
Score of 6-7 = at least 40.9% risk
'TIMI risk' estimates mortality following acute coronary syndrome
s. TIMI risk can be calculated on the TIMI website under "Clinical Calculators."
Thrombolysis
Thrombolysis is the breakdown of blood clots by pharmacological means. It is colloquially referred to as clot busting for this reason...
In Myocardial Infarction
Myocardial infarction
Myocardial infarction or acute myocardial infarction , commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die...
' and is the name of an Academic Research Organization (ARO) which was founded by Dr. Eugene Braunwald
Eugene Braunwald
- Biography :Eugene Braunwald, an eminent American cardiologist, was born August 15, 1929 to Jewish parents Wilhelm Braunwald and Clara Wallach in Vienna....
in 1984. It has conducted numerous practice-changing clinical trials in patients with cardiovascular disease or risk factors for cardiovascular disease.
The TIMI Study Group is affiliated with Brigham and Women's Hospital and Harvard Medical School, and is chaired by Dr. Marc Sabatine (founding Chairman Eugene Braunwald
Eugene Braunwald
- Biography :Eugene Braunwald, an eminent American cardiologist, was born August 15, 1929 to Jewish parents Wilhelm Braunwald and Clara Wallach in Vienna....
, MD (1982-2010)). Its headquarters are located in Boston, MA with a second location in Quincy, MA.
Active Trials
- IMPROVE-IT (TIMI 40)
- ENGAGE-AF-TIMI 48
- TRA2P-TIMI 50
- ATLAS II-TIMI 51
- SOLID-TIMI 52
- SAVOR-TIMI 53
- PEGASUS-TIMI 54
- REVEAL-TIMI 55
- ELEVATE-TIMI 56
TIMI Risk Score
The TIMI Risk Score is used in patients with Unstable Angina / Non-ST Elevation Myocardial Infarction. It is used to categorize a patient's risk of death and ischemic events and provides a basis for therapeutic decision making.TIMI Score Calculation (1 point for each):
-Age >= 65
-Aspirin use in the last 7 days (patient experiences chest pain despite ASA use in past 7days)
-At least 2 angina episodes within the last 24hrs
-ST changes of at least 0.5mm on admission EKG
-Elevated serum cardiac biomarkers
-Known Coronary Artery Disease (CAD) (coronary stenosis >= 50%)
- At least 3 risk factors for CAD, such as: Hypertension -> 140/90 or on antihypertensives, Cigarette smoking, HDL < 40, Diabetes,
Family history of premature CAD (CAD in male first-degree relative, or father less than 55, or female first-degree relative or mother less than 65).
Score Interpretation:
% risk at 14 days of: all-cause mortality, new or recurrent MI, or severe recurrent ischemia requiring urgent revascularization.
Score of 0-1 = 4.7% risk
Score of 2 = 8.3% risk
Score of 3 = 13.2% risk
Score of 4 = 19.9% risk
Score of 5 = 26.2% risk
Score of 6-7 = at least 40.9% risk
'TIMI risk' estimates mortality following acute coronary syndrome
Acute coronary syndrome
Acute coronary syndrome is usually one of three diseases involving the coronary arteries: ST elevation myocardial infarction , non ST elevation myocardial infarction , or unstable angina ....
s. TIMI risk can be calculated on the TIMI website under "Clinical Calculators."
TIMI Grade Flow
'TIMI Grade Flow' is a scoring system from 0-3 referring to levels of coronary blood flow assessed during percutaneous coronary angioplasty:- TIMI 0 flow (no perfusion) refers to the absence of any antegrade flow beyond a coronary occlusion.
- TIMI 1 flow (penetration without perfusion) is faint antegrade coronary flow beyond the occlusion, with incomplete filling of the distal coronary bed.
- TIMI 2 flow (partial reperfusion) is delayed or sluggish antegrade flow with complete filling of the distal territory.
- TIMI 3 flow (complete perfusion) is normal flow which fills the distal coronary bed completely