T-HCA
Encyclopedia
T-HCA, or trans-4-hydroxycrotonic acid, is a drug used in scientific research. It is structurally related to GHB
and binds to the GHB receptor
with 4-fold higher affinity than GHB itself, but is not an agonist for the primary sedative target of GHB, the GABAB receptor, and so does not produce sedative effects, instead causing convulsion
s thought to be mediated through increased glutamate release. It may also be naturally produced in the mammalian CNS and is suspected to be an endogenous ligand for the GHB receptor.
Gamma-Hydroxybutyric acid
γ-Hydroxybutyric acid , also known as 4-hydroxybutanoic acid and sodium oxybate when used for medicinal purposes, is a naturally occurring substance found in the central nervous system, wine, beef, small citrus fruits, and almost all animals in small amounts. It is also categorized as an illegal...
and binds to the GHB receptor
GHB receptor
Gamma-hydroxybutyrate receptor or GHB receptor , originally identified as GPR172A, is a G protein-coupled receptor that binds gamma-Hydroxybutyric acid .-History:...
with 4-fold higher affinity than GHB itself, but is not an agonist for the primary sedative target of GHB, the GABAB receptor, and so does not produce sedative effects, instead causing convulsion
Convulsion
A convulsion is a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body. Because a convulsion is often a symptom of an epileptic seizure, the term convulsion is sometimes used as a synonym for seizure...
s thought to be mediated through increased glutamate release. It may also be naturally produced in the mammalian CNS and is suspected to be an endogenous ligand for the GHB receptor.