Steven J. Burakoff
Encyclopedia
Steven J. Burakoff, MD, is a cancer
specialist and the author of both Therepeutic Immunology (2001) and Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment (1990).
.
Before joining Mount Sinai, he was recruited by NYU
to revitalize the research and treatment mission of NYU's Cancer Institute, which during his tenure experienced a 31 percent growth and a 50 percent increase in NCI
funding.
He completed a residency
in medicine at New York Hospital-Cornell Medical Center and pursued fellowships
in immunology
at both Rockefeller University
and Harvard Medical School
.
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
specialist and the author of both Therepeutic Immunology (2001) and Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment (1990).
Biography
Burakoff is the Director of the Mount Sinai Medical Center’s Cancer Institute, which was created in 2007 to focus on translational medicineTranslational medicine
Translational medicine is a medical practice based on interventional epidemiology. It is regarded by its proponents as a natural progression from Evidence-Based Medicine. It integrates research from the basic sciences, social sciences and political sciences with the aim of optimising patient care...
.
Before joining Mount Sinai, he was recruited by NYU
New York University School of Medicine
The New York University School of Medicine is one of the graduate schools of New York University. Founded in 1841 as the University Medical College, the NYU School of Medicine is one of the foremost medical schools in the United States....
to revitalize the research and treatment mission of NYU's Cancer Institute, which during his tenure experienced a 31 percent growth and a 50 percent increase in NCI
National Cancer Institute
The National Cancer Institute is part of the National Institutes of Health , which is one of 11 agencies that are part of the U.S. Department of Health and Human Services. The NCI coordinates the U.S...
funding.
He completed a residency
Residency (medicine)
Residency is a stage of graduate medical training. A resident physician or resident is a person who has received a medical degree , Podiatric degree , Dental Degree and who practices...
in medicine at New York Hospital-Cornell Medical Center and pursued fellowships
Fellowship (medicine)
A fellowship is the period of medical training in the United States and Canada that a physician may undertake after completing a specialty training program . During this time , the physician is known as a fellow...
in immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
at both Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
and Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
.
Appointments and positions
- Director of The Mount Sinai Medical Center’s Cancer Institute http://www.mountsinai.org
- Formerly Laura and Isaac PerlmutterIsaac PerlmutterIsaac "Ike" Perlmutter is an American businessman and financier. He has been the Chief Executive Officer of Marvel Entertainment since January 1, 2005. He was also the owner of Remington Products and Toy Biz.-Background:...
Professor, New York University School of Medicine - Past Director, New York University Cancer Institute
- Past Director, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
- Past Chair of Pediatric OncologyOncologyOncology is a branch of medicine that deals with cancer...
at the Dana-Farber Cancer InstituteDana-Farber Cancer InstituteDana–Farber Cancer Institute is part of a Comprehensive Cancer Center designated by the National Cancer Institute. It is a major affiliate of Harvard Medical School and is located in the Longwood Medical Area in Boston, Massachusetts.-Overview:... - Formerly Margaret M. Dyson Professor of Pediatrics at the Harvard Medical SchoolHarvard Medical SchoolHarvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
- Former Ted Williams Senior Investigator at the Dana-Farber Cancer Institute
- Former Member, Board of Trustees of the Dana-Farber Cancer Institute
- Board of Directors, Pharmacopeia Drug Discovery, Inc.
Education
- Lehigh UniversityLehigh UniversityLehigh University is a private, co-educational university located in Bethlehem, Pennsylvania, in the Lehigh Valley region of the United States. It was established in 1865 by Asa Packer as a four-year technical school, but has grown to include studies in a wide variety of disciplines...
with a Bachelor of Science degree - Master’s degree from Queens CollegeQueens College, City University of New YorkQueens College, located in Flushing, Queens, New York City, is one of the senior colleges of the City University of New York. It is also the fifth oldest of the City University's twenty-three institutions of higher learning. The college's seventy seven acre campus is located in the heart of the...
- M.D. from Albany Medical CollegeAlbany Medical CollegeAlbany Medical College is a medical school located in Albany, New York, United States. It was founded in 1839 by Amos Dean, Dr. Thomas Hun and others, and is one of the oldest medical schools in the nation...
- Honorary Master’s of Science Degree from Harvard UniversityHarvard UniversityHarvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
Books
- Strom TB, Austen KF, Burakoff SJ. Therepeutic Immunology. Wiley-Blackwell, 2001 ISBN 0-632-04359-8
- Ferrara JLM, Deeg HJ, Burakoff SJ. Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment. Marcel Dekker, 1990 ISBN 0-8247-9728-0
Other publications (partial list)
- Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction. Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ. J Biol Chem. 2008 PMID 18586679
- Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation. Jin YJ, Cai CY, Zhang X, Burakoff SJ. J Immunol. 2008 PMID 18523251
- Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway. Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. The journal of biological chemistry, 2007 PMID 17895239
- From bytes to bedside: data integration and computational biology for translational cancer research. Mathew JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AMArul ChinnaiyanArul Chinnaiyan is a Hicks Endowed Professor of Pathology and professor of pathology and urology at the University of Michigan Medical School. He is also a Howard Hughes medical Investigator at the Howard Hughes Medical Institute....
, Sander C, Burakoff SJ, Mishra B. PLoS computational biology, 2007 PMID 17319736 - A CD8/Lck transgene is able to drive thymocyte differentiation. Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. Journal of immunology, 2006 PMID 17056525
- HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. Journal of immunology, 2005 PMID 16116206
- CD4 phosphorylation partially reverses Nef down-regulation of CD4. Jin YJ, Zhang X, Boursiquot JG, Burakoff SJ. Journal of immunology, 2004 PMID 15494497
- Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D, Modiano JF. The journal of pharmacology and experimental therapeutics, 2004 PMID 15231866
- SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ. Blood, 2004 PMID 15205258
- Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing. Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. European journal of immunology, 2004 PMID 15307178
- Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. Journal of the American society of blood and marrow transplantation, 2004 PMID 15205666
- Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. Slavik JM, Lim DG, Burakoff SJ, Hafler DA., Journal of biological chemistry, 2004 PMID 14573608