State Road 65 is a north–south route in the eastern Panhandle

Florida Panhandle

The Florida Panhandle, an informal, unofficial term for the northwestern part of Florida, is a strip of land roughly 200 miles long and 50 to 100 miles wide , lying between Alabama on the north and the west, Georgia also on the north, and the Gulf of Mexico to the south. Its eastern boundary is...

, running from a junction with US 98/319 near Eastpoint

Eastpoint, Florida

Eastpoint is a census-designated place in Franklin County, Florida, United States. The population was 2,158 at the 2000 census.-Geography:Eastpoint is located at ....

 northwards through the Apalachicola National Forest

Apalachicola National Forest

The Apalachicola National Forest is the largest U.S. National Forest in the state of Florida. It contains and is the only national forest located in the Florida Panhandle. The Apalachicola National Forest contains two Wilderness Areas, Bradwell Bay and Mudswamp/New River...

 to SR 12 west of Quincy

Quincy, Florida

Quincy is a city in Gadsden County, Florida, United States. The population was 6,982 at the 2000 census. As of 2004, the population recorded by the U.S. Census Bureau is 6,975...

, near US 90.

Originally, SR 65 was co-signed with US 90 to Quincy, then north alone to the Georgia border, where it becomes State Route 241. Sometime in the 1990s , FDOT downloaded the stretch of SR 65 from Quincy to the Georgia border to the Gadsden County

Gadsden County, Florida

Gadsden County is a county located in the panhandle of the U.S. state of Florida. As of the 2000 census, the population was 45,087. The U.S. Census Bureau 2005 estimate for the county is 46,428 . Its county seat is Quincy, Florida. Gadsden County is the only predominantly African-American...

government, in which that segment became County Road 65.