State Highway 53 is a 87 mile (139 km) highway in southern Oklahoma

Oklahoma

Oklahoma is a state located in the South Central region of the United States of America. With an estimated 3,751,351 residents as of the 2010 census and a land area of 68,667 square miles , Oklahoma is the 28th most populous and 20th-largest state...

. It connects Walters

Walters, Oklahoma

Walters is a city in Cotton County, Oklahoma, United States. The population was 2,657 at the 2000 census. The city, nestled in between twin creeks, is the county seat of Cotton County...

 in Cotton Co.

Cotton County, Oklahoma

Cotton County is a county located in the U.S. state of Oklahoma. As of 2000, the population was 6,614. Its county seat is Walters.When Oklahoma achieved statehood in 1907, the area which is now Cotton County fell within the boundaries of Comanche County...

 to Gene Autry

Gene Autry, Oklahoma

Gene Autry is a town in Carter County, Oklahoma, United States. The population was 99 at the 2000 census. It is part of the Ardmore, Oklahoma Micropolitan Statistical Area.-History:...

 in Carter Co.

Carter County, Oklahoma

Carter County is a county located in the U.S. state of Oklahoma. As of 2010, the population was 47,557. Its county seat is Ardmore.Carter County is part of the Ardmore, Oklahoma, Micropolitan Statistical Area.-Geography:According to the U.S...

. It has one lettered spur route, SH-53A.
SH-53 begins at a T intersection in Walters, where State Highway 5

State Highway 5 (Oklahoma)

State Highway 5 is the name assigned to two distinct state highways in the U.S state of Oklahoma. One runs for 21 miles through extreme southwestern Oklahoma, passing through Harmon and Jackson Counties...

 makes up the western and southern legs of the T. SH-53 runs eastward from here, crossing East Cache Creek. At Fivemile Corner, the road intersects SH-65, five miles (8 km) east of Walters.