Spirapril
Encyclopedia
Spirapril hydrochloride (Renormax) is an ACE inhibitor
antihypertensive
drug used to treat hypertension
.
Like many ACE inhibitors, this is a prodrug
which is converted to the active metabolite spiraprilat
following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes which may allow for greater use in patients with renal impairment.
However data on its effect upon the renal function
is conflicting.
It is produced synthetically by combining the following two pharmaceutical intermediates:
(S)-1,4 Dithia-7-azaspiro (4,4)-nonane-8-(s)-carboxylic acid hydrobromide
CAS 75776-79-3
and
N-[1-(s)-ethoxycarbonyl-3-phenylpropyl)-L-Alanine ( ECPPA) http://www.mainpluschem.com/Spirapril/spirapril.html
ACE inhibitor
ACE inhibitors or angiotensin-converting enzyme inhibitors are a group of drugs used primarily for the treatment of hypertension and congestive heart failure...
antihypertensive
Antihypertensive
The antihypertensives are a class of drugs that are used to treat hypertension . Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from...
drug used to treat hypertension
Hypertension
Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...
.
Like many ACE inhibitors, this is a prodrug
Prodrug
A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...
which is converted to the active metabolite spiraprilat
Spiraprilat
Spiraprilat is the active metabolite of Spirapril....
following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes which may allow for greater use in patients with renal impairment.
However data on its effect upon the renal function
Renal function
Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate describes the flow rate of filtered fluid through the kidney...
is conflicting.
It is produced synthetically by combining the following two pharmaceutical intermediates:
(S)-1,4 Dithia-7-azaspiro (4,4)-nonane-8-(s)-carboxylic acid hydrobromide
CAS 75776-79-3
and
N-[1-(s)-ethoxycarbonyl-3-phenylpropyl)-L-Alanine ( ECPPA) http://www.mainpluschem.com/Spirapril/spirapril.html