Spectrum Pharmaceuticals is an American biopharmaceutical company. The company is located in Irvine, California

Irvine, California

Irvine is a suburban incorporated city in Orange County, California, United States. It is a planned city, mainly developed by the Irvine Company since the 1960s. Formally incorporated on December 28, 1971, the city has a population of 212,375 as of the 2010 census. However, the California...

.

Approved drugs

In the US, Spectrum markets Fusilev and Zevalin.

Fusilev (Levoleucovorin) for injection is a drug that was approved by the U.S. Food and Drug Administration in 2008 for the US; the drug had been on the market in a number of European countries.

Zevalin, as part of the Zevalin therapeutic regimen, is indicated for the treatment of patients with relapsed or refractory, low‑grade or follicular B‑cell non‑Hodgkin's lymphoma (NHL), including patients with rituximab refractory follicular NHL. It has been approved by the FDA in 2002.

In development

A number of drugs are currently investigated in clinical trial

Clinical trial

Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...

s.

EOquin (Apaziquone

Apaziquone

Apaziquone is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active...

) is a synthetic bio-reductive prodrug

Prodrug

A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...

 intended for the treatment of non-invasive bladder cancer

Bladder cancer

Bladder cancer is any of several types of malignant growths of the urinary bladder. It is a disease in which abnormal cells multiply without control in the bladder. The bladder is a hollow, muscular organ that stores urine; it is located in the pelvis...

 that is currently in Phase 3 studies. Allergan

Allergan

Allergan, Inc., is a global specialty pharmaceutical company. Their product ranges include ophthalmic pharmaceuticals, dermatology products, and neurological products.-Profile:...

 has invested money in 2008 to help develop this medication further and bring it to the market.
In Phase 2 studies are Ozarelix, for the treatment of prostate cancer

Prostate cancer

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...

 and benign prostatic hypertrophy, Ortataxel

Ortataxel

Ortataxel is a drug used in chemotherapy., Spectrum Pharmaceuticals has the drug is in a Phase 2 clinical trial....

, for the treatment of taxane

Taxane

The taxanes are diterpenes produced by the plants of the genus Taxus . As their name suggests, they were first derived from natural sources, but some have been synthesized artificially. Taxanes include paclitaxel and docetaxel . Paclitaxel was originally derived from the Pacific yew tree.Taxanes...

-refractory tumors, and Satraplatin

Satraplatin

Satraplatin is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration...

,for non-small cell lung cancer (NSCLC).

Other medications are in development or Phase 1 studies.

External links

• Official site