Sortilin 1
Encyclopedia
Sortilin is a protein
that in humans is encoded by the SORT1 gene
. The SORT1 locus shows the strongest association with serum lipoprotein
s of any genetic locus in the genome. In hepatocyte
s, sortilin participates in the presecretory degradation of nascent VLDL particles.
with GGA1
and GGA2
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SORT1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The SORT1 locus shows the strongest association with serum lipoprotein
Lipoprotein
A lipoprotein is a biochemical assembly that contains both proteins and lipids water-bound to the proteins. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins...
s of any genetic locus in the genome. In hepatocyte
Hepatocyte
A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver's cytoplasmic mass.These cells are involved in:* Protein synthesis* Protein storage* Transformation of carbohydrates...
s, sortilin participates in the presecretory degradation of nascent VLDL particles.
Interactions
Sortilin 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with GGA1
GGA1
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.-Interactions:GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3.-Further reading:...
and GGA2
GGA2
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.-Interactions:GGA2 has been shown to interact with RABEP1, Sortilin 1, BACE2 and CLINT1.-Further reading:...
.