Somatomedin
Encyclopedia
Somatomedin is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division . In this way, they mediate the effect of somatotropin (also known as growth hormone
).
They have similar biological effects to somatotropin.
Three forms include:
Growth hormone
Growth hormone is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior...
).
They have similar biological effects to somatotropin.
Three forms include:
- somatomedin A, which is another name for insulin-like growth factor 2Insulin-like growth factor 2Insulin-like growth factor 2 is one of three protein hormones that share structural similarity to insulin.-Gene structure:In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted genes. In mice this homologous region is found at distal chromosome 7...
- somatomedin BSomatomedin BSomatomedin B is a serum factor of unknown function, is a small cysteine-rich peptide, derived proteolytically from the N-terminus of the cell-substrate adhesion protein vitronectin...
, which is derived from vitronectinVitronectinVitronectin also known as VTN is a protein that in humans is encoded by the VTN gene.The protein encoded by this gene is a member of the pexin family... - somatomedin C, which is another name for insulin-like growth factor 1Insulin-like growth factor 1Insulin-like growth factor 1 also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" in the 1970s.IGF-1 is a hormone similar in molecular...