Sodium-hydrogen antiporter 3
Encyclopedia
Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein
that in humans is encoded by the SLC9A3 gene
.
SLC9A3 is a sodium–hydrogen antiporter. It is found in the nephron
of the kidney
and in the apical membrane of enterocytes of the intestine
. It is primarily responsible for maintaining the balance of sodium
.
stimulates NHE3, while protein kinase A inhibits it.
There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1
.
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SLC9A3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
SLC9A3 is a sodium–hydrogen antiporter. It is found in the nephron
Nephron
The renal tubule is the portion of the nephron containing the tubular fluid filtered through the glomerulus. After passing through the renal tubule, the filtrate continues to the collecting duct system, which is not part of the nephron....
of the kidney
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
and in the apical membrane of enterocytes of the intestine
Intestine
In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine...
. It is primarily responsible for maintaining the balance of sodium
Sodium
Sodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...
.
Regulation
Protein kinase CProtein kinase C
Protein kinase C also known as PKC is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in...
stimulates NHE3, while protein kinase A inhibits it.
There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1
Sodium-hydrogen antiporter 3 regulator 1
Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 or Na+/H+ Exchanger Regulatory Factor...
.
Interactions
Sodium-hydrogen antiporter 3 has been shown to interact with CHPCHP (gene)
Calcium binding protein P22, also known as CHP, is a human gene.-Interactions:CHP has been shown to interact with Sodium-hydrogen antiporter 1 and Sodium-hydrogen antiporter 3.-Further reading:...
.