Sodium-hydrogen antiporter
Encyclopedia
The sodium–hydrogen antiporter or sodium–hydrogen exchanger is a membrane protein
found in many cells, and especially in those of the nephron
of the kidney
. It is primarily responsible for maintaining the balance of sodium
.
Membrane protein
A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. More than half of all proteins interact with membranes.-Function:...
found in many cells, and especially in those of the nephron
Nephron
The renal tubule is the portion of the nephron containing the tubular fluid filtered through the glomerulus. After passing through the renal tubule, the filtrate continues to the collecting duct system, which is not part of the nephron....
of the kidney
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
. It is primarily responsible for maintaining the balance of sodium
Sodium
Sodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...
.
Isoforms
There are several isoforms of the antiporter:- Sodium–hydrogen antiporter 1
- Sodium–hydrogen antiporter 2SLC9A2Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.-Further reading:...
- Sodium–hydrogen antiporter 3
- Sodium–hydrogen antiporter 5SLC9A5Sodium–hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.-Further reading:...
- Sodium–hydrogen antiporter 6SLC9A6Sodium/hydrogen exchanger 6 is a protein that in humans is encoded by the SLC9A6 gene.-Further reading:...
- Sodium–hydrogen antiporter 8SLC9A8Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.-Further reading:...