Sereny test
Encyclopedia
The Sereny test is a test used to test the invasiveness of organisms such as Escherichia coli
Escherichia coli
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...

.

It is also used on Listeria monocytogenes.

It is done by inoculating suspension of bacteria into guinea pig's eye. Severe mucopurulent conjunctivitis
Conjunctivitis
Conjunctivitis refers to inflammation of the conjunctiva...

 and severe keratitis
Keratitis
Keratitis is a condition in which the eye's cornea, the front part of the eye, becomes inflamed. The condition is often marked by moderate to intense pain and usually involves impaired eyesight.-Types:...

indicates a positive test.
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