Sel-12
Encyclopedia
The Caenorhabditis elegans
sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin
. sel-12 positively regulates the lin-12 and glp-1 Notch signaling
pathways during hermaphrodite gonadal, vulval, and germline development. sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).
C. elegans gene abbreviations: sel, Suppressor/Enhancer of Lin-12; lin, cell LINeage defective; glp, Germ Line Proliferation defective.
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Caenorhabditis elegans
Caenorhabditis elegans is a free-living, transparent nematode , about 1 mm in length, which lives in temperate soil environments. Research into the molecular and developmental biology of C. elegans was begun in 1974 by Sydney Brenner and it has since been used extensively as a model...
sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin
Presenilin
Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase intramembrane protease complex...
. sel-12 positively regulates the lin-12 and glp-1 Notch signaling
Notch signaling
The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass...
pathways during hermaphrodite gonadal, vulval, and germline development. sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).
C. elegans gene abbreviations: sel, Suppressor/Enhancer of Lin-12; lin, cell LINeage defective; glp, Germ Line Proliferation defective.
External links
sel-12 gene summary (WormBaseWormBase
WormBase is an online bioinformatics database of the biology and genome of the model organism Caenorhabditis elegans and related nematodes....
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