Secondary cold contact urticaria
Encyclopedia
Secondary cold contact urticaria is a cutaneous condition characterized by wheal
Wheal
Wheal may refer to:*Wheal response, a cutaneous condition left by a blow or as part of an allergic reaction*Wheal, a Cornish mine...

s, due to serum abnormalities such as cryoglobulinemia
Cryoglobulinemia
Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins - proteins that become insoluble at reduced temperatures. Cryoglobulins typically precipitate at temperatures below normal body temperature and will dissolve again if the blood is heated...

 or cryofibrinogenemia
Cryofibrinogenemia
Cryofibrinogenemia is defined by the presence of circulating cold insoluble complexes of fibrin, fibrinogen, fibronectin, and fibrin split products with albumin, immunoglobulins and plasma proteins that precipitate from the patient's plasma in the cold....

 are extremely rare, and are then associated with other manifestations such as Raynaud's phenomenon
Raynaud's phenomenon
In medicine, Raynaud's phenomenon is a vasospastic disorder causing discoloration of the fingers, toes, and occasionally other areas. This condition can also cause nails to become brittle with longitudinal ridges. Named for French physician Maurice Raynaud , the phenomenon is believed to be the...

or purpura.
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