Schizophyllan
Encyclopedia
Schizophyllan, abbreviated SPG in clinical trial literature, is a neutral extracellular polysaccharide
produced by the fungus Schizophyllum commune
, consisting of a 1,3-β-D-linked backbone of glucose residues with 1,6-β-D-glucosyl side groups. Schizophyllan is also known as sizofiran
.
The non-degraded polysaccharide has a molecular weight of the order 106 Da. A chemically analogous polysaccharide, scleroglucan, is formed by the fungus Sclerotium rolfsii. Both polysaccharides share the chemical structure of the backbone with curdlan
. It is known for several things, including its ability to stimulate the immune system, carry metals in water, aid in delivering drugs, and use in some nanofibers.
Polysaccharide
Polysaccharides are long carbohydrate molecules, of repeated monomer units joined together by glycosidic bonds. They range in structure from linear to highly branched. Polysaccharides are often quite heterogeneous, containing slight modifications of the repeating unit. Depending on the structure,...
produced by the fungus Schizophyllum commune
Schizophyllum commune
Schizophyllum commune is a very common species of mushroom in the genus Schizophyllum. It is the world's most widely distributed mushroom, occurring on every continent except Antarctica....
, consisting of a 1,3-β-D-linked backbone of glucose residues with 1,6-β-D-glucosyl side groups. Schizophyllan is also known as sizofiran
Sizofiran
Sizofiran is a beta-glucan, also known as schizophyllan and abbreviated as SPG in many papers. It is a polysaccharide consisting of repeating β-linked D-glucse units with occasional β-branches. This generates a very stiff triple-helical structure in water....
.
The non-degraded polysaccharide has a molecular weight of the order 106 Da. A chemically analogous polysaccharide, scleroglucan, is formed by the fungus Sclerotium rolfsii. Both polysaccharides share the chemical structure of the backbone with curdlan
Curdlan
Curdlan is a high molecular weight polymer of glucose. Curdlan consists of β--linked glucose residues and forms elastic gels upon heating in aqueous suspension.It is produced by Agrobacterium biobar, a non pathogenic bacteria....
. It is known for several things, including its ability to stimulate the immune system, carry metals in water, aid in delivering drugs, and use in some nanofibers.