, a region of 7.15 million people which includes San Jose
and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121.5 km²) on the northern end of the San Francisco Peninsula
, giving it a density of about 17,179 people per square mile (6,632 people per km2).
1776 Father Francisco Palou founds Mission San Francisco de Asis in what is now San Francisco, California.
1847 Yerba Buena, California is renamed San Francisco.
1848 California Gold Rush: The first ship with Chinese immigrants arrives in San Francisco, California.
1852 Congress establishes the United States' 2nd mint in San Francisco, California.
1873 The University of California opens its first medical school in San Francisco, California.
1876 An express train called the ''Transcontinental Express'' arrives in San Francisco, California, via the First Transcontinental Railroad only 83 hours and 39 minutes after leaving New York City.
1892 In San Francisco, California, John Muir organizes the Sierra Club.
1906 San Francisco public school board sparks United States diplomatic crisis with Japan by ordering Japanese students to be taught in racially segregated schools.
1907 Bubonic plague breaks out in San Francisco, California.
1916 In San Francisco, California, a bomb explodes on Market Street during a Preparedness Day parade killing 10 and injuring 40.