STX8
Encyclopedia
Syntaxin-8 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the STX8 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 has been shown to form the SNARE
Snare
Snare may refer to:* Snare trap, a kind of trap used for capturing animals* Snare drum* SNARE , a family of proteins involved in vesicle fusion* The Snares, a group of islands approximately 200 kilometres south of New Zealand...

 complex with syntaxin 7, vti1b
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene.-Further reading:...

 and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.

Interactions

STX8 has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Vesicle-associated membrane protein 8
Vesicle-associated membrane protein 8
Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.-Interactions:Vesicle-associated membrane protein 8 has been shown to interact with STX4, SNAP23, STX1A, STX8 and STX7.-Further reading:...

, VTI1B
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene.-Further reading:...

 and STX7
STX7
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.In melanocytic cells STX7 gene expression may be regulated by MITF.-Interactions:STX7 has been shown to interact with STX8, VPS18, Vesicle-associated membrane protein 8 and VPS11....

.

Further reading

The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
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