SR-142,948
Encyclopedia
SR-142,948 is a drug used in scientific research which is a non-peptide antagonist selective for the neurotensin receptor
s, although not selective between subtypes. It has been used to study the role of neurotensin
in the regulation of dopamine receptor
activity and glutamate signalling in the brain, and in animal studies SR-142,948 blocked the effects of stimulant drugs, including MDMA.
Neurotensin receptor
The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the and genes contain seven transmembrane helices and are G protein coupled...
s, although not selective between subtypes. It has been used to study the role of neurotensin
Neurotensin
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system...
in the regulation of dopamine receptor
Dopamine receptor
Dopamine receptors are a class of metabotropic G protein-coupled receptors that are prominent in the vertebrate central nervous system . The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors....
activity and glutamate signalling in the brain, and in animal studies SR-142,948 blocked the effects of stimulant drugs, including MDMA.