SPPL2A
Encyclopedia
Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene
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-like protease (SPPL) family and encodes an endosomal membrane protein with the conserved active site motifs 'YD' and 'GxGD' in in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. A pseudogene of this gene also lies on chromosome 15.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
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Function
This gene is a member of the signal peptide peptidaseSignal Peptide Peptidase
The Signal Peptide Peptidase is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in in adjacent transmembrane domains . Its sequences is highly conserved in different vertebrate species...
-like protease (SPPL) family and encodes an endosomal membrane protein with the conserved active site motifs 'YD' and 'GxGD' in in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. A pseudogene of this gene also lies on chromosome 15.