SPINK6
Encyclopedia
Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein
encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal
proteases involved in maintaining skin homeostasis, including KLK5
, KLK7
and KLK14
. SPINK6 is a member of a gene family cluster located on chromosome
5q33.1, which includes SPINK5
and SPINK9.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal
Epidermis
Epidermis may refer to:* Epidermis , in plants, the outermost layer of cells covering the leaves and young parts of a plant* Epidermis , the outermost layer of the skin of a human...
proteases involved in maintaining skin homeostasis, including KLK5
KLK5
Kallikrein-related peptidase 5 , formerly known as stratum corneum tryptic enzyme , is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is...
, KLK7
KLK7
Kallikrein-related peptidase 7 is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme...
and KLK14
KLK14
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.-External Links:* The MEROPS online database for peptidases and their inhibitors:...
. SPINK6 is a member of a gene family cluster located on chromosome
Chromosome
A chromosome is an organized structure of DNA and protein found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions.Chromosomes...
5q33.1, which includes SPINK5
SPINK5
Lympho-epithelial Kazal-type-related inhibitor also known as serine protease inhibitor Kazal-type 5 is a protein that in humans is encoded by the SPINK5 gene.- Structure and function :...
and SPINK9.