SNAP-7941
Encyclopedia
SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone
receptor
MCH1
. In initial animal studies it had promising anxiolytic
, antidepressant
and anorectic
effects, but subsequent trial results were disappointing, and the main significance of SNAP-7941 is as the lead compound
from which more potent and selective antagonists such as SNAP-94847
were developed, although it continues to be used for research into the function of the MCH1 receptor.
Melanin concentrating hormone
Melanin-concentrating hormone is a cyclic 19-amino acid orexinogenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation....
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
MCH1
Melanin-concentrating hormone receptor 1
Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the human melanin-concentrating hormone receptors.-Function:...
. In initial animal studies it had promising anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
, antidepressant
Antidepressant
An antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia and anxiety disorders such as social anxiety disorder. According to Gelder, Mayou &*Geddes people with a depressive illness will experience a therapeutic effect to their mood;...
and anorectic
Anorectic
An anorectic or anorexic , also known as anorexigenic or appetite suppressant, is a dietary supplement and/or drug which reduces appetite, food consumption, and as a result, causes weight loss to occur.-List of anorectics:Numerous pharmaceutical compounds are marketed as appetite suppressants.The...
effects, but subsequent trial results were disappointing, and the main significance of SNAP-7941 is as the lead compound
Lead compound
A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters.Lead compounds are often found in...
from which more potent and selective antagonists such as SNAP-94847
SNAP-94847
SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects, and also reduces food consumption suggesting a possible...
were developed, although it continues to be used for research into the function of the MCH1 receptor.