Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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The demonstration that SKAP1 regulates LFA-1

LFA-1

Lymphocyte function-associated antigen 1, also known as LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first...

 adhesion was made by retroviral infection and by the SKAP1 deficient mouse . Additional work has implicated SKAP1 in binding to the exchange factor

Guanine nucleotide exchange factor

Guanine nucleotide exchange factors activate monomeric GTPases by stimulating the release of guanosine diphosphate to allow binding of guanosine triphosphate . A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity...

 RasGRP1

RASGRP1

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.- Function :RAS guanyl nucleotide-releasing protein is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor domain...

 and in regulating ERK

Extracellular signal-regulated kinases

In molecular biology, extracellular-signal-regulated kinases or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells...

 activation in T-cells .

Interactions

SKAP1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with FYN

FYN

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth...

, PTPRC and FYB

FYB

FYN binding protein , also known as FYB, ADAP , and SLAP-130 is a protein that in humans is encoded by the FYB gene....

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Further reading