SILV
Encyclopedia
Melanocyte protein Pmel 17 is a protein
that in humans is encoded by the SILV gene
. Its gene product may be referred to as silver, ME20, gp100 or Pmel17 and is a 100 kDa type I transmembrane protein. Its processing results in the formation of non-pathological aggregates that form the melanosomal
striation.
The SILV gene is regulated by the microphthalmia-associated transcription factor
. (MITF)
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SILV gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. Its gene product may be referred to as silver, ME20, gp100 or Pmel17 and is a 100 kDa type I transmembrane protein. Its processing results in the formation of non-pathological aggregates that form the melanosomal
Melanosome
In a biological cell, a melanosome is an organelle containing melanin, the most common light-absorbing pigment found in the animal kingdom.Cells that synthesize melanins are called melanocytes, and also the retinal pigment epithelium cells, whereas cells that have merely engulfed the melanosomes...
striation.
The SILV gene is regulated by the microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development.-Clinical significance:...
. (MITF)