SIBLING proteins
Encyclopedia
The family of non-collagen
ous protein
s known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, included proteins that exist in the extracellular matrix
of bone
and dentin
and are believed to play key roles in the mineralization
of these two substances.
The following are categorized as SIBLING proteins:
The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.
Collagen
Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...
ous protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
s known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, included proteins that exist in the extracellular matrix
Extracellular matrix
In biology, the extracellular matrix is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions. The extracellular matrix is the defining feature of connective tissue in animals.Extracellular...
of bone
Bone
Bones are rigid organs that constitute part of the endoskeleton of vertebrates. They support, and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue is a type of dense connective tissue...
and dentin
Dentin
Dentine is a calcified tissue of the body, and along with enamel, cementum, and pulp is one of the four major components of teeth. Usually, it is covered by enamel on the crown and cementum on the root and surrounds the entire pulp...
and are believed to play key roles in the mineralization
Mineralization (biology)
In biology, mineralization refers to the process where an organic substance is converted to an inorganic substance.This may also be a normal biological process which takes place during the life of an organism such as the formation of bone tissue or egg shells, largely with calcium.This term may...
of these two substances.
The following are categorized as SIBLING proteins:
- osteopontinOsteopontinOsteopontin , also known as bone sialoprotein I , early T-lymphocyte activation , secreted phosphoprotein 1 , 2ar and Rickettsia resistance , is a human gene product, which is also conserved in other species...
(OPN) - bone sialoproteinBone sialoproteinBone sialoprotein is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum...
(BSP) - dentin matrix protein 1 (DMP1)
- dentin sialophosphoproteinDentin sialophosphoproteinDentin sialophosphoprotein may refer to a number of things:* dentin sialophosphoprotein, a protein produced by odontoblasts* dentin sialophosphoprotein, the gene that encodes for the abovementioned protein...
(DSPP) - matrix extracellular phosphoglycoprotein (MEPE)
The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.