Ruzicka large ring synthesis
The Ruzicka large ring synthesis or Ruzicka reaction or Ruzicka cyclization is an organic reaction
Organic reaction
Organic reactions are chemical reactions involving organic compounds. The basic organic chemistry reaction types are addition reactions, elimination reactions, substitution reactions, pericyclic reactions, rearrangement reactions, photochemical reactions and redox reactions. In organic synthesis,...

 in which a dicarboxylic acid
Dicarboxylic acid
Dicarboxylic acids are organic compounds that contain two carboxylic acid functional groups. In molecular formulae for dicarboxylic acids, these groups are often written as HOOC-R-COOH, where R may be an alkyl, alkenyl, alkynyl, or aryl group...

 is converted to a cyclic ketone
In organic chemistry, a ketone is an organic compound with the structure RCR', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group bonded to two other carbon atoms. Many ketones are known and many are of great importance in industry and in biology...

 at high temperature and a suitable catalyst such as thorium oxide. The reaction is named after Lavoslav Ružička
Lavoslav Ružicka
Lavoslav Ružička FRS born as Lavoslav Ružička was a Croatian scientist and winner of the 1939 Nobel Prize in Chemistry who worked most of his life in Switzerland...

 who invented it in 1926.

The reaction has been applied in the synthesis of Exaltone, a synthetic Muscone
Muscone is an organic compound that is the primary contributor to the odor of musk.The chemical structure of muscone was first elucidated by Lavoslav Ružička. It consists of a 15-membered ring ketone with one methyl substituent in the 3-position. It is an oily liquid that is found naturally as...

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