Rnd1 is a small signaling G protein

G protein

G proteins are a family of proteins involved in transmitting chemical signals outside the cell, and causing changes inside the cell. They communicate signals from many hormones, neurotransmitters, and other signaling factors. G protein-coupled receptors are transmembrane receptors...

 (more specifically a GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

), and is a member of the Rnd subgroup of the Rho family of GTPases

Rho family of GTPases

The Rho family of GTPases is a family of small signaling G protein , and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants...

.. It is encoded by the gene RND1.

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]

Interactions

Rnd1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with GRB7

GRB7

Growth factor receptor-bound protein 7, also known as GRB7, is a protein which in humans is encoded by the GRB7 gene.- Function :The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules...

, PLXNB1

PLXNB1

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.-Interactions:PLXNB1 has been shown to interact with ARHGEF12, Rnd1 and ARHGEF11.-Further reading:...

, PDE6D

PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.-Interactions:...

, ARHGAP5

ARHGAP5

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.-Interactions:ARHGAP5 has been shown to interact with Rnd1, Rnd2, Rnd3 and RHOA.-Further reading:...

 and UBXD5

UBXD5

UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.-Interactions:UBXD5 has been shown to interact with Rnd1, Rnd2 and Rnd3.-Further reading:...

.

Further reading