Renal agenesis
Encyclopedia
Renal agenesis is a unilateral or bilateral medical condition in which one or both fetal kidney
s fail to develop leading to oligohydramnios
, resulting in a 40-fold increase in perinatal mortality.
It can be associated with RET
or UPK3A
.
s to develop during gestation
, and is one causative agent of Potter sequence. This absence of kidneys causes oligohydramnios
, a deficiency of amniotic fluid in a pregnant woman, which can place extra pressure on the developing baby and cause further malformations. The condition is frequently, but not always the result of a genetic disorder
, and is more common in infants born to one or more parents with a malformed or absent kidney. Males are more commonly affected and most infants that are born alive do not live beyond four hours.
abnormalities which are abnormalities of the development of the female reproductive tract and can be a cause of infertility. The odds of a person being born with this condition are roughly 1 in 750. Adults with unilateral renal agenesis have considerably higher chances of hypertension (high blood pressure). People with this condition are advised to approach contact sports with caution.
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
s fail to develop leading to oligohydramnios
Oligohydramnios
Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the opposite of polyhydramnios.-Diagnosis:Diagnosis is made by ultrasound measurement of the amniotic fluid index...
, resulting in a 40-fold increase in perinatal mortality.
It can be associated with RET
RET proto-oncogene
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules....
or UPK3A
UPK3A
Uroplakin-3a is a protein that in humans is encoded by the UPK3A gene.-Further reading:...
.
Bilateral
Bilateral renal agenesis is the uncommon and serious failure of both a fetus' kidneyKidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
s to develop during gestation
Gestation
Gestation is the carrying of an embryo or fetus inside a female viviparous animal. Mammals during pregnancy can have one or more gestations at the same time ....
, and is one causative agent of Potter sequence. This absence of kidneys causes oligohydramnios
Oligohydramnios
Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the opposite of polyhydramnios.-Diagnosis:Diagnosis is made by ultrasound measurement of the amniotic fluid index...
, a deficiency of amniotic fluid in a pregnant woman, which can place extra pressure on the developing baby and cause further malformations. The condition is frequently, but not always the result of a genetic disorder
Genetic disorder
A genetic disorder is an illness caused by abnormalities in genes or chromosomes, especially a condition that is present from before birth. Most genetic disorders are quite rare and affect one person in every several thousands or millions....
, and is more common in infants born to one or more parents with a malformed or absent kidney. Males are more commonly affected and most infants that are born alive do not live beyond four hours.
Unilateral renal agenesis
This is much more common, but is not usually of any major health consequence, as long as the other kidney is healthy. It is associated with an increased incidence of mullerian ductMüllerian duct
Müllerian ducts are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the Müllerian eminence in the primitive urogenital sinus. In the female, they will develop to form the Fallopian tubes, uterus, cervix, and the upper two-third of the vagina; in...
abnormalities which are abnormalities of the development of the female reproductive tract and can be a cause of infertility. The odds of a person being born with this condition are roughly 1 in 750. Adults with unilateral renal agenesis have considerably higher chances of hypertension (high blood pressure). People with this condition are advised to approach contact sports with caution.