Reeler domain
Encyclopedia
Reeler domain is a protein domain
.
Extracellular matrix
(ECM) proteins play an important role in early cortical development, specifically in the formation of neural connections and in controlling the cyto-architecture of the central nervous system. The product of the reeler gene in mouse is reelin
, a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. F-spondin
and mindin are a family of matrix-attached adhesion molecules
that share structural similarities and overlapping domains of expression. Both F-spondin and mindin promote adhesion and outgrowth of hippocampal embryonic neurons and bind to a putative receptor(s) expressed on both hippocampal and sensory neurons.
This domain of unknown function is found at the N terminus of reelin and F-spondin.
FRRS1, RELN
, SPON1
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
.
Extracellular matrix
Extracellular matrix
In biology, the extracellular matrix is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions. The extracellular matrix is the defining feature of connective tissue in animals.Extracellular...
(ECM) proteins play an important role in early cortical development, specifically in the formation of neural connections and in controlling the cyto-architecture of the central nervous system. The product of the reeler gene in mouse is reelin
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
, a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. F-spondin
Spondin 1
Spondin-1 is a protein that in humans is encoded by the SPON1 gene. The protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.-Further reading:...
and mindin are a family of matrix-attached adhesion molecules
Cell adhesion molecule
Cell Adhesion Molecules are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix in the process called cell adhesion....
that share structural similarities and overlapping domains of expression. Both F-spondin and mindin promote adhesion and outgrowth of hippocampal embryonic neurons and bind to a putative receptor(s) expressed on both hippocampal and sensory neurons.
This domain of unknown function is found at the N terminus of reelin and F-spondin.
Examples
Human genes that encode proteins containing the reeler domain include:FRRS1, RELN
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
, SPON1
Spondin 1
Spondin-1 is a protein that in humans is encoded by the SPON1 gene. The protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.-Further reading:...