Ranuccio Farnese (1509–1529)
Encyclopedia
Ranuccio Farnese was the natural son of Alessandro Farnese
Pope Paul III
Pope Paul III , born Alessandro Farnese, was Pope of the Roman Catholic Church from 1534 to his death in 1549. He came to the papal throne in an era following the sack of Rome in 1527 and rife with uncertainties in the Catholic Church following the Protestant Reformation...

 by Silvia Ruffini, born before his father was elected pope as Paul III. His siblings were Pier Luigi, Paul and Costanza
Costanza Farnese
Costanza Farnese was a daughter of Alessandro Farnese and Silvia Ruffini, born before her father became Pope Paul III. Her siblings were Pier Luigi, Paul and Ranuccio. Costanza's own children included Guido Ascanio and her grandchildren included Costanza Sforza....

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