Radixin
Encyclopedia
Radixin is a protein
that in humans is encoded by the RDX gene
.
Radixin is a cytoskeletal protein that may be important in linking actin
to the plasma membrane. It is highly similar in sequence to both ezrin and moesin
. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene
(RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack intron
s (RDXP1) was mapped to 11p by Southern and PCR analyses.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the RDX gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Radixin is a cytoskeletal protein that may be important in linking actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...
to the plasma membrane. It is highly similar in sequence to both ezrin and moesin
Moesin
Moesin is a protein that in humans is encoded by the MSN gene.Moesin is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons...
. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene
Pseudogene
Pseudogenes are dysfunctional relatives of known genes that have lost their protein-coding ability or are otherwise no longer expressed in the cell...
(RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack intron
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
s (RDXP1) was mapped to 11p by Southern and PCR analyses.