RU28362
Encyclopedia
RU28362 is a molecule which binds the glucocorticoid receptor
(Corticoid Type II Receptor) but not the mineralocorticoid receptor
(Corticoid Type I Receptor).
This is in contrast to cortisol
, which binds both receptors, though it binds Type II with greater affinity.
Glucocorticoid receptor
The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....
(Corticoid Type II Receptor) but not the mineralocorticoid receptor
Mineralocorticoid receptor
The mineralocorticoid receptor , also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.MR is a receptor with high affinity for mineralocorticoids...
(Corticoid Type I Receptor).
This is in contrast to cortisol
Cortisol
Cortisol is a steroid hormone, more specifically a glucocorticoid, produced by the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat,...
, which binds both receptors, though it binds Type II with greater affinity.