RTI-32
Encyclopedia
-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane
-based cocaine
analog that is important in the field of medicinal chemistry
for performing SAR
.
It has similar properties in vitro to related drugs such as RTI-31
.
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
Comparison of Data
| Compound > DAT
DA
NET
NA
SERT
5HT
| Troparil 23
49.8
550
37.2
178
173
| RTI-32 1.7
7.02
36
8.42
23
19.4
| RTI-31
1.1
3.68
22
5.86
4.0
5.0
| 3'4'-xylyl
0.43
unknown
44
unknown
2.42
unknown
Phenyltropane
Phenyltropanes were originally developed to reduce cocaine addiction and dependency. In general these compounds act as inhibitors of the plasmalemmal monoamine reuptake transporters. Although RTI holds a strong position in this field, they are not the only researchers that have prepared these...
-based cocaine
Cocaine
Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is a stimulant of the central nervous system, an appetite suppressant, and a topical anesthetic...
analog that is important in the field of medicinal chemistry
Medicinal chemistry
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with design, chemical synthesis and development for market of pharmaceutical...
for performing SAR
Structure-activity relationship
The structure–activity relationship is the relationship between the chemical or 3D structure of a molecule and its biological activity. The analysis of SAR enables the determination of the chemical groups responsible for evoking a target biological effect in the organism...
.
It has similar properties in vitro to related drugs such as RTI-31
RTI-31
-2β-Carbomethoxy-3β-tropane is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the article, RTI-31 is 64 x the strength of cocaine in terms of its potency to elicit...
.
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
| Compound >
| Troparil
| RTI-32
| RTI-31
RTI-31
-2β-Carbomethoxy-3β-tropane is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the article, RTI-31 is 64 x the strength of cocaine in terms of its potency to elicit...
| 3'4'-xylyl
Xylyl
A xylyl is one of a group of chemical radicals denoted by the formula 2C6H3. Xylyls are derived from three xylenes with a hydrogen atom removed....