Pyrabactin
Encyclopedia
Pyrabactin is a synthetic sulfonamide
that mimics abscisic acid
(ABA), a naturally produced stress hormone
in plants that helps them cope with drought conditions by inhibiting growth. ABA can be manufactured for agricultural use; however, ABA is light-sensitive and costly to make. Pyrabactin is relatively inexpensive, easy to make, and not sensitive to light. Unlike ABA, pyrabactin activates only a few of the 14 ABA receptors in the plant needed for effective drought tolerance. Its role as an ABA mimic may make pyrabactin an important tool for protecting crops against drought and cold weather.
The discovery of pyrabactin by Sean Cutler
was named a breakthrough research of 2009 by Science
magazine.
Pyrabactin (for pyridyl containing ABA activator) is a naphthalene sulfonamide hypocotyl cell expansion inhibitor. A combination of genetic, transcriptomic and physiological evidence demonstrated that pyrabactin activates the ABA pathway in a manner very similar to ABA. As such, pyrabactin is the first ABA agonist that is not an ABA analog and may ultimately lead to the development of a new family of synthetic plant growth regulators.
(IUPAC Name = 4-Bromo-N-(2-pyridinylmethyl)-1-napthalenesulfonamide, 4-Bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide. CAS No = 419538-69-5. Appearance = powder, white to off-white. Solubility = DMSO: >10 mg/mL)
Sulfonamide
Sulfonamide or sulphonamide may refer to:*Sulfonamide – the sulfonamide functional group. *Sulfonamide – the group of sulfonamide antibacterial drugs....
that mimics abscisic acid
Abscisic acid
Abscisic acid , also known as abscisin II and dormin, is a plant hormone. ABA functions in many plant developmental processes, including bud dormancy. It is degraded by the enzyme -abscisic acid 8'-hydroxylase.-Function:...
(ABA), a naturally produced stress hormone
Hormone
A hormone is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from one...
in plants that helps them cope with drought conditions by inhibiting growth. ABA can be manufactured for agricultural use; however, ABA is light-sensitive and costly to make. Pyrabactin is relatively inexpensive, easy to make, and not sensitive to light. Unlike ABA, pyrabactin activates only a few of the 14 ABA receptors in the plant needed for effective drought tolerance. Its role as an ABA mimic may make pyrabactin an important tool for protecting crops against drought and cold weather.
The discovery of pyrabactin by Sean Cutler
Sean Cutler
Sean R. Cutler is an associate professor of plant cell biology and chemistry at the University of California, Riverside. In 2009 Cutler showed how abscisic acid, a naturally-produced plant stress hormone, helps plants survive by inhibiting their growth in times of drought. Cutler also discovered...
was named a breakthrough research of 2009 by Science
Science (journal)
Science is the academic journal of the American Association for the Advancement of Science and is one of the world's top scientific journals....
magazine.
Pyrabactin (for pyridyl containing ABA activator) is a naphthalene sulfonamide hypocotyl cell expansion inhibitor. A combination of genetic, transcriptomic and physiological evidence demonstrated that pyrabactin activates the ABA pathway in a manner very similar to ABA. As such, pyrabactin is the first ABA agonist that is not an ABA analog and may ultimately lead to the development of a new family of synthetic plant growth regulators.
(IUPAC Name = 4-Bromo-N-(2-pyridinylmethyl)-1-napthalenesulfonamide, 4-Bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide. CAS No = 419538-69-5. Appearance = powder, white to off-white. Solubility = DMSO: >10 mg/mL)