PyBOP
Encyclopedia
PyBOP is a peptide coupling reagent
used in solid phase peptide synthesis
. It is used as a substitute for the BOP reagent
, thus avoiding the formation of the carcinogenic side product HMPA.
Reagent
A reagent is a "substance or compound that is added to a system in order to bring about a chemical reaction, or added to see if a reaction occurs." Although the terms reactant and reagent are often used interchangeably, a reactant is less specifically a "substance that is consumed in the course of...
used in solid phase peptide synthesis
Peptide synthesis
In organic chemistry, peptide synthesis is the production of peptides, which are organic compounds in which multiple amino acids are linked via amide bonds which are also known as peptide bonds...
. It is used as a substitute for the BOP reagent
BOP reagent
BOP-reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage....
, thus avoiding the formation of the carcinogenic side product HMPA.
See also
- BOP reagentBOP reagentBOP-reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage....
(Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate)