Psychotridine
Encyclopedia
Psychotridine is a alkaloid
found in some species of the Psychotria
genus, namely Psychotria colorata
, but also Psychotria forsteriana
, Psychotria lyciiflora, Psychotria oleoides, and Psychotria beccarioides. Psychotridine has analgesic
effects and dose-dependently inhibits dizocilpine
binding to cortical membranes in vitro, suggesting that it acts as a non-competitive
NMDA receptor antagonist
.
Alkaloid
Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...
found in some species of the Psychotria
Psychotria
Psychotria is a plant genus of 1900 species in the family Rubiaceae. Members of the genus are low trees in tropical forests. The distinction between Psychotria and the genus Cephaelis are not well known and many species were formerly placed there....
genus, namely Psychotria colorata
Psychotria colorata
Psychotria colorata is a species of plant in the Rubiaceae family. It has been documented in an ethnobotanical context among the Ka'apor people of Maranhão, Brazil by Dr. William Balée, the Tulane University anthropologist and historical ecologist:...
, but also Psychotria forsteriana
Psychotria forsteriana
Psychotria forsteriana is a South American rainforest understory shrub from the coffee family, Rubiaceae....
, Psychotria lyciiflora, Psychotria oleoides, and Psychotria beccarioides. Psychotridine has analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
effects and dose-dependently inhibits dizocilpine
Dizocilpine
Dizocilpine , also known as MK-801, is a non-competitive antagonist of the N-methyl-d-aspartate receptor, a glutamate receptor. Glutamate is the brain's primary excitatory neurotransmitter...
binding to cortical membranes in vitro, suggesting that it acts as a non-competitive
Non-competitive inhibition
Non-competitive inhibition is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme, by binding not to the active site on the enzyme, but to a different site...
NMDA receptor antagonist
NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor . They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia...
.