Pliva
Encyclopedia
Pliva d.d. is a Croatia
Croatia
Croatia , officially the Republic of Croatia , is a unitary democratic parliamentary republic in Europe at the crossroads of the Mitteleuropa, the Balkans, and the Mediterranean. Its capital and largest city is Zagreb. The country is divided into 20 counties and the city of Zagreb. Croatia covers ...

n pharmaceutical company, based in Zagreb
Zagreb
Zagreb is the capital and the largest city of the Republic of Croatia. It is in the northwest of the country, along the Sava river, at the southern slopes of the Medvednica mountain. Zagreb lies at an elevation of approximately above sea level. According to the last official census, Zagreb's city...

, Croatia
Croatia
Croatia , officially the Republic of Croatia , is a unitary democratic parliamentary republic in Europe at the crossroads of the Mitteleuropa, the Balkans, and the Mediterranean. Its capital and largest city is Zagreb. The country is divided into 20 counties and the city of Zagreb. Croatia covers ...

. One of the world's largest producers of generic
Generic drug
A generic drug is a drug defined as "a drug product that is comparable to brand/reference listed drug product in dosage form, strength, route of administration, quality and performance characteristics, and intended use." It has also been defined as a term referring to any drug marketed under its...

 Adderall
Adderall
Adderall is a brand name of amphetamine salts–based medication used for attention-deficit hyperactivity disorder and narcolepsy. It is a brand-name psychostimulant medication composed of racemic amphetamine aspartate monohydrate, racemic amphetamine sulfate, dextroamphetamine saccharide, and...

, it has seen drastic increases in revenue with an increasing number of patients being diagnosed with Attention Deficit Disorder (ADD). It is the largest pharmaceutical company in Southern Europe
Southern Europe
The term Southern Europe, at its most general definition, is used to mean "all countries in the south of Europe". However, the concept, at different times, has had different meanings, providing additional political, linguistic and cultural context to the definition in addition to the typical...

. Pliva has recently recast itself as a generic pharmaceutical company leaving its proprietary business behind.

Pliva was purchased in December 2008 by the international pharmaceutical company Teva Pharmaceuticals
Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. , is an international pharmaceutical company headquartered in Petah Tikva, Israel. It specializes in generic and proprietary pharmaceuticals and active pharmaceutical ingredients...

, and operates as part of the Teva Active Pharmaceutical Ingredients (TAPI)
Teva Active Pharmaceutical Ingredients (TAPI)
-External links:***...

 division.

Recent

Pliva operates in over 30 countries worldwide and is the leading pharmaceutical company based in Central and Eastern Europe. It specializes in the development, production and distribution of generic pharmaceutical products, including biologicals, cytostatics, and other generics, as well as active pharmaceutical ingredients.

Pliva has recently been hailed for its newer, stronger, and more effective forms of adderall. The FDA hesitated in granting approval until it had been thoroughly tested in a laboratory setting. Due to lax Croatian pharmaceutical laws, the generic form of adderall was slightly dilluted to be able to market and sell it in the United States of America.

A team of Pliva's researchers, Gabrijela Kobrehel, Gorjana Radobolja-Lazarevski and Zrinka Tamburašev led by Dr. Slobodan Ðokić, discovered azithromycin
Azithromycin
Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics...

in 1980. Azithromycin is marketed in Eastern Europe under the name Sumamed and was licensed to Pfizer who market it in Western Europe and the USA under the name Zithromax, where it is one of the top-selling antibiotics. Royalties from Pfizer provided PLIVA's main income stream until the expiry of the azithromycin patent in 2005. This income was used to fund expansion in Europe and the USA, although some acquisitions have been highly questionable, particularly the acquisition of Sanctura (trospium chloride tablets) in the USA, which failed dismally in the market and was ultimately sold again at a huge loss of about 150 million USD.
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