Pipecolic acid
Encyclopedia
Pipecolic acid is a small organic molecule which accumulates in pipecolic acidemia
. It is the carboxylic acid of piperidine
.
It can be associated with some forms of epilepsy
.
CRYM
, a taxon-specific crystallin
protein that also binds thyroid hormone
s, is involved in the pipecolic acid pathway.
Pipecolic acid was identified in the Murchison meteorite
.
Pipecolic acidemia
Pipecolic acidemia, also called hyperpipecolic acidemia or hyperpipecolatemia, is a very rare autosomal recessive metabolic disorder that is caused by a peroxisomal defect....
. It is the carboxylic acid of piperidine
Piperidine
Piperidine is an organic compound with the molecular formula 5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom...
.
It can be associated with some forms of epilepsy
Epilepsy
Epilepsy is a common chronic neurological disorder characterized by seizures. These seizures are transient signs and/or symptoms of abnormal, excessive or hypersynchronous neuronal activity in the brain.About 50 million people worldwide have epilepsy, and nearly two out of every three new cases...
.
CRYM
CRYM
Mu-crystallin homolog also known as NADP-regulated thyroid-hormone-binding protein is a protein that in humans is encoded by the CRYM gene. Multiple alternatively spliced transcript variants have been found for this gene.- Function :...
, a taxon-specific crystallin
Crystallin
In anatomy, a crystallin is a water-soluble structural protein found in the lens and the cornea of the eye accounting for the transparency of the structure. It has also been identified in other places such as the heart, and in aggressive breast cancer tumors....
protein that also binds thyroid hormone
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...
s, is involved in the pipecolic acid pathway.
Pipecolic acid was identified in the Murchison meteorite
Murchison meteorite
The Murchison meteorite is named after Murchison, Victoria, in Australia. It is one of the most studied meteorites due to its large mass , the fact that it was an observed fall, and it belongs to a group of meteorites rich in organic compounds....
.