Pinacidil
Encyclopedia
Pinacidil is a cyanoguanidine
drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arteriole
s. It reduces blood pressure
and peripheral resistance and produces fluid retention.
2-Cyanoguanidine
2-Cyanoguanidine or commonly dicyandiamide is an nitrile derived from guanidine. It is a dimer of cyanamide, from which it can be prepared. 2-Cyanoguanidine is a colourless solid that is soluble in water, acetone, and alcohol, but not in diethyl ether or chloroform.-Production and...
drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arteriole
Arteriole
An arteriole is a small diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries.Arterioles have muscular walls and are the primary site of vascular resistance...
s. It reduces blood pressure
Blood pressure
Blood pressure is the pressure exerted by circulating blood upon the walls of blood vessels, and is one of the principal vital signs. When used without further specification, "blood pressure" usually refers to the arterial pressure of the systemic circulation. During each heartbeat, BP varies...
and peripheral resistance and produces fluid retention.