Phosphoramidate
Encyclopedia
A phosphoramidate is a phosphate
that has an NR2 instead of an OH group. The structure of phosphoramidic acid (phosphoramidate), (HO)2PONH2, is present in PubChem
.
A phosphorodiamidate is a phosphate
that has two of its OH groups substituted by NR2 groups.
.
An examples of a phosphorodiamidate is Morpholino
which is used in molecular biology
.
Phosphate
A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in...
that has an NR2 instead of an OH group. The structure of phosphoramidic acid (phosphoramidate), (HO)2PONH2, is present in PubChem
PubChem
PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information , a component of the National Library of Medicine, which is part of the United States National Institutes of Health . PubChem can...
.
A phosphorodiamidate is a phosphate
Phosphate
A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in...
that has two of its OH groups substituted by NR2 groups.
Examples
An example of a natural phosphoramidate is phosphocreatinePhosphocreatine
Phosphocreatine, also known as creatine phosphate or PCr , is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and brain.-Chemistry:...
.
An examples of a phosphorodiamidate is Morpholino
Morpholino
In molecular biology, a Morpholino is a molecule in a particular structural family that is used to modify gene expression. Morpholino oligomers are an antisense technology used to block access of other molecules to specific sequences within nucleic acid...
which is used in molecular biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
.