Phorbol 12,13-dibutyrate
Encyclopedia
Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil
. As an activator of protein kinase C
, it is a weak tumor promoter compared to 12-O-Tetradecanoylphorbol-13-acetate
.
PDBu is widely used as a chemical reagent because of its solubility
in water and other organic solvents.
Croton oil
Croton oil is an oil prepared from the seeds of Croton tiglium, a tree belonging to the natural order Euphorbiales and family Euphorbiaceae, and native or cultivated in India and the Malay Archipelago. Small doses taken internally cause diarrhea. Externally, the oil can cause irritation and swelling...
. As an activator of protein kinase C
Protein kinase C
Protein kinase C also known as PKC is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in...
, it is a weak tumor promoter compared to 12-O-Tetradecanoylphorbol-13-acetate
12-O-Tetradecanoylphorbol-13-acetate
12-O-tetradecanoylphorbol-13-acetate , also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate , is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein...
.
PDBu is widely used as a chemical reagent because of its solubility
Solubility
Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent. The solubility of a substance fundamentally depends on the used solvent as well as on...
in water and other organic solvents.